4EYR
Crystal structure of multidrug-resistant clinical isolate 769 HIV-1 protease in complex with ritonavir
Summary for 4EYR
Entry DOI | 10.2210/pdb4eyr/pdb |
Related | 1TW7 3OQ7 |
Related PRD ID | PRD_001001 |
Descriptor | HIV-1 PROTEASE, RITONAVIR (3 entities in total) |
Functional Keywords | protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Human immunodeficiency virus 1 |
Total number of polymer chains | 2 |
Total formula weight | 22260.21 |
Authors | Liu, Z.,Yedidi, R.S.,Wang, Y.,Brunzelle, J.S.,Kovari, I.A.,Kovari, L.C. (deposition date: 2012-05-01, release date: 2013-01-30, Last modification date: 2024-02-28) |
Primary citation | Liu, Z.,Yedidi, R.S.,Wang, Y.,Dewdney, T.G.,Reiter, S.J.,Brunzelle, J.S.,Kovari, I.A.,Kovari, L.C. Insights into the mechanism of drug resistance: X-ray structure analysis of multi-drug resistant HIV-1 protease ritonavir complex. Biochem.Biophys.Res.Commun., 431:232-238, 2013 Cited by PubMed: 23313846DOI: 10.1016/j.bbrc.2012.12.127 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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