4EYR
Crystal structure of multidrug-resistant clinical isolate 769 HIV-1 protease in complex with ritonavir
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | HIV-1 PROTEASE | polymer | 99 | 10769.6 | 2 | UniProt (Q000H7) Pfam (PF00077) | Human immunodeficiency virus 1 | |
| 2 | C (B) | RITONAVIR | non-polymer | 720.9 | 1 | BIRD (PRD_001001) Chemie (RIT) | |||
| 3 | D, E (A, B) | water | water | 18.0 | 247 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 99 (UniProt: Q000H7)
| PDB | External Database | Details |
|---|---|---|
| Asn 25 | Asp 25 | variant |
| Glu 35 | Asp 35 | variant |
| Val 36 | Ile 36 | variant |
| Leu 46 | Met 46 | variant |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 21539.3 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 720.9 | |
| All* | Total formula weight | 22260.2 |
