4EU2
Crystal structure of 20s proteasome with novel inhibitor K-7174
Summary for 4EU2
Entry DOI | 10.2210/pdb4eu2/pdb |
Descriptor | Proteasome component C7-alpha, Proteasome component PUP3, Proteasome component C11, ... (16 entities in total) |
Functional Keywords | proteasome inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Saccharomyces cerevisiae (Baker's yeast) More |
Cellular location | Cytoplasm: P21243 P25451 P22141 P30656 P23724 P30657 P23639 P23638 P40303 P32379 P40302 P21242 P38624 P25043 |
Total number of polymer chains | 28 |
Total formula weight | 707188.29 |
Authors | Kikuchi, J.,Shibayama, N.,Yamada, S.,Wada, T.,Nobuyoshi, M.,Izumi, T.,Akutsu, M.,Kano, Y.,Ohki, M.,Sugiyama, K.,Park, S.-Y.,Furukawa, Y. (deposition date: 2012-04-25, release date: 2013-05-01, Last modification date: 2024-03-20) |
Primary citation | Kikuchi, J.,Shibayama, N.,Yamada, S.,Wada, T.,Nobuyoshi, M.,Izumi, T.,Akutsu, M.,Kano, Y.,Sugiyama, K.,Ohki, M.,Park, S.Y.,Furukawa, Y. Homopiperazine derivatives as a novel class of proteasome inhibitors with a unique mode of proteasome binding. Plos One, 8:e60649-e60649, 2013 Cited by PubMed: 23593271DOI: 10.1371/journal.pone.0060649 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.509 Å) |
Structure validation
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