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4EOI

Thr 160 phosphorylated CDK2 K89D, Q131E - human cyclin A3 complex with the inhibitor RO3306

Summary for 4EOI
Entry DOI10.2210/pdb4eoi/pdb
Related4EOJ 4EOK 4EOL 4EOM 4EON 4EOO 4EOP 4EOQ 4EOR 4EOS
DescriptorCyclin-dependent kinase 2, Cyclin-A2, (5E)-5-(quinolin-6-ylmethylidene)-2-[(thiophen-2-ylmethyl)amino]-1,3-thiazol-4(5H)-one, ... (6 entities in total)
Functional Keywordsprotein kinase, cell cycle, phosphorylation, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceHomo sapiens (human)
More
Cellular locationCytoplasm, cytoskeleton, centrosome: P24941
Nucleus: P20248
Total number of polymer chains4
Total formula weight128506.81
Authors
Echalier, A.,Cot, E.,Camasses, A.,Hodimont, E.,Hoh, F.,Sheinerman, F.,Krasinska, L.,Fisher, D. (deposition date: 2012-04-14, release date: 2013-02-06)
Primary citationEchalier, A.,Cot, E.,Camasses, A.,Hodimont, E.,Hoh, F.,Jay, P.,Sheinerman, F.,Krasinska, L.,Fisher, D.
An integrated chemical biology approach provides insight into Cdk2 functional redundancy and inhibitor sensitivity.
Chem.Biol., 19:1028-1040, 2012
Cited by
PubMed: 22921070
DOI: 10.1016/j.chembiol.2012.06.015
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2 Å)
Structure validation

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