4EOI
Thr 160 phosphorylated CDK2 K89D, Q131E - human cyclin A3 complex with the inhibitor RO3306
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, C | Cyclin-dependent kinase 2 | polymer | 299 | 34130.4 | 2 | UniProt (P24941) Pfam (PF00069) In PDB | Homo sapiens (human) | Cell division protein kinase 2, p33 protein kinase |
2 | B, D | Cyclin-A2 | polymer | 258 | 29624.3 | 2 | UniProt (P20248) Pfam (PF00134) Pfam (PF02984) In PDB | Homo sapiens (human) | Cyclin-A |
3 | A, C | (5E)-5-(quinolin-6-ylmethylidene)-2-[(thiophen-2-ylmethyl)amino]-1,3-thiazol-4(5H)-one | non-polymer | 351.4 | 2 | Chemie (1RO) | |||
4 | A | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 1 | Chemie (DMS) | |||
5 | B, D | MONOTHIOGLYCEROL | non-polymer | 108.2 | 2 | Chemie (SGM) | |||
6 | water | water | 18.0 | 423 | Chemie (HOH) |
Sequence modifications
A, C: 1 - 298 (UniProt: P24941)
PDB | External Database | Details |
---|---|---|
Ser 0 | - | EXPRESSION TAG |
Asp 89 | Lys 89 | ENGINEERED MUTATION |
Glu 131 | Gln 131 | ENGINEERED MUTATION |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 127509.5 | |
Non-Polymers* | Number of molecules | 5 |
Total formula weight | 997.3 | |
All* | Total formula weight | 128506.8 |