4EH4

Human p38 MAP kinase in complex with NP-F3 and RL87

Summary for 4EH4

Entry DOI	10.2210/pdb4eh4/pdb
Related	4EH2 4EH3 4EH5 4EH6 4EH7 4EH8 4EH9
Descriptor	Mitogen-activated protein kinase 14, N~4~-cyclopropyl-2-phenylquinazoline-4,7-diamine, phenyl(piperidin-1-yl)methanone, ... (4 entities in total)
Functional Keywords	map kinase insert, kinase-ligand complex, np-fragment, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: Q16539
Total number of polymer chains	1
Total formula weight	41734.65
Authors	Over, B.,Gruetter, C.,Waldmann, H.,Rauh, D. (deposition date: 2012-04-02, release date: 2012-12-05, Last modification date: 2023-09-13)
Primary citation	Over, B.,Wetzel, S.,Grutter, C.,Nakai, Y.,Renner, S.,Rauh, D.,Waldmann, H. Natural-product-derived fragments for fragment-based ligand discovery. Nat Chem, 5:21-28, 2012 Cited by PubMed: 23247173 DOI: 10.1038/nchem.1506 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation