4EH9

Human p38 MAP kinase in complex with NP-F11 and RL87

Summary for 4EH9

• Entry DOI: 10.2210/pdb4eh9/pdb
• Related: 4EH2 4EH3 4EH4 4EH5 4EH6 4EH7 4EH8
• Descriptor: Mitogen-activated protein kinase 14, N~4~-cyclopropyl-2-phenylquinazoline-4,7-diamine, (1R,5S)-3-[4-(trifluoromethyl)benzoyl]-1,2,3,4,5,6-hexahydro-8H-1,5-methanopyrido[1,2-a][1,5]diazocin-8-one, ... (4 entities in total)
• Functional Keywords: map kinase insert, kinase-ligand complex, allosteric pocket, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm: Q16539
• Total number of polymer chains: 1
• Total formula weight: 41907.74

Authors

Over, B.,Gruetter, C.,Waldmann, H.,Rauh, D. (deposition date: 2012-04-02, release date: 2012-12-05, Last modification date: 2023-09-13)

• Primary citation: Over, B.,Wetzel, S.,Grutter, C.,Nakai, Y.,Renner, S.,Rauh, D.,Waldmann, H.; Natural-product-derived fragments for fragment-based ligand discovery.; Nat Chem, 5:21-28, 2012; PubMed: 23247173; DOI: 10.1038/nchem.1506

Experimental method

X-RAY DIFFRACTION (2.1 Å)