4EE0
Crystal structure of hH-PGDS with water displacing inhibitor
Summary for 4EE0
Entry DOI | 10.2210/pdb4ee0/pdb |
Related | 4EDY 4EDZ |
Descriptor | Hematopoietic prostaglandin D synthase, MAGNESIUM ION, 4-(isoquinolin-1-yl)-N-[2-(morpholin-4-yl)ethyl]benzamide, ... (5 entities in total) |
Functional Keywords | inhibitor, solvent replacement, isomerase-isomerase inhibitor complex, isomerase/isomerase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: O60760 |
Total number of polymer chains | 2 |
Total formula weight | 48181.39 |
Authors | Day, J.E.,Thorarensen, A.,Trujillo, J.I. (deposition date: 2012-03-28, release date: 2012-07-18, Last modification date: 2024-02-28) |
Primary citation | Trujillo, J.I.,Kiefer, J.R.,Huang, W.,Day, J.E.,Moon, J.,Jerome, G.M.,Bono, C.P.,Kornmeier, C.M.,Williams, M.L.,Kuhn, C.,Rennie, G.R.,Wynn, T.A.,Carron, C.P.,Thorarensen, A. Investigation of the binding pocket of human hematopoietic prostaglandin (PG) D2 synthase (hH-PGDS): a tale of two waters. Bioorg.Med.Chem.Lett., 22:3795-3799, 2012 Cited by PubMed: 22546671DOI: 10.1016/j.bmcl.2012.04.004 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.75 Å) |
Structure validation
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