4EDY

Crystal structure of hH-PGDS with water displacing inhibitor

Summary for 4EDY

Entry DOI	10.2210/pdb4edy/pdb
Related	4EDZ 4EE0
Descriptor	Hematopoietic prostaglandin D synthase, MAGNESIUM ION, GLUTATHIONE, ... (6 entities in total)
Functional Keywords	inhibitor, solvent replacement, isomerase-isomerase inhibitor complex, isomerase/isomerase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: O60760
Total number of polymer chains	2
Total formula weight	47863.12
Authors	Day, J.E.,Thorarensen, A.,Trujillo, J.I.,Kiefer, J.R. (deposition date: 2012-03-27, release date: 2012-10-03, Last modification date: 2024-02-28)
Primary citation	Trujillo, J.I.,Kiefer, J.R.,Huang, W.,Day, J.E.,Moon, J.,Jerome, G.M.,Bono, C.P.,Kornmeier, C.M.,Williams, M.L.,Kuhn, C.,Rennie, G.R.,Wynn, T.A.,Carron, C.P.,Thorarensen, A. Investigation of the binding pocket of human hematopoietic prostaglandin (PG) D2 synthase (hH-PGDS): a tale of two waters. Bioorg.Med.Chem.Lett., 22:3795-3799, 2012 Cited by PubMed: 22546671 DOI: 10.1016/j.bmcl.2012.04.004 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.72 Å)

Structure validation