4E93

Crystal structure of human Feline Sarcoma Viral Oncogene Homologue (v-FES)in complex with TAE684

Summary for 4E93

Entry DOI	10.2210/pdb4e93/pdb
Related	3BKB
Descriptor	Tyrosine-protein kinase Fes/Fps, 5-CHLORO-N-[2-METHOXY-4-[4-(4-METHYLPIPERAZIN-1-YL)PIPERIDIN-1-YL]PHENYL]-N'-(2-PROPAN-2-YLSULFONYLPHENYL)PYRIMIDINE-2,4-DIAMINE (3 entities in total)
Functional Keywords	v-fes, fujinami, avian sarcoma, viral, oncogene, feline sarcoma virus, atp-binding, kinase, nucleotide-binding, phosphoprotein, proto-oncogene, sh2 domain, transferase, tyrosine-protein kinase, transferase-transferase inhibitor complex, structural genomics, structural genomics consortium, sgc, transferase/transferase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm, cytosol: P07332
Total number of polymer chains	1
Total formula weight	43372.24
Authors	Filippakopoulos, P.,Salah, E.,Miduturu, C.V.,Fedorov, O.,Cooper, C.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Weigelt, J.,Gray, N.S.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2012-03-20, release date: 2012-04-18, Last modification date: 2023-09-13)
Primary citation	Hellwig, S.,Miduturu, C.V.,Kanda, S.,Zhang, J.,Filippakopoulos, P.,Salah, E.,Deng, X.,Choi, H.G.,Zhou, W.,Hur, W.,Knapp, S.,Gray, N.S.,Smithgall, T.E. Small-Molecule Inhibitors of the c-Fes Protein-Tyrosine Kinase. Chem.Biol., 19:529-540, 2012 Cited by PubMed: 22520759 DOI: 10.1016/j.chembiol.2012.01.020 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.84 Å)

Structure validation