4DZ3
Crystal structure of a Peptidyl-prolyl cis-trans isomerase with surface mutation M61H from Burkholderia pseudomallei complexed with FK506
Summary for 4DZ3
Entry DOI | 10.2210/pdb4dz3/pdb |
Related | 2ke0 2ko7 2l2s 3uf8 3uqa 3uqb 3vaw 4DZ2 |
Descriptor | Peptidyl-prolyl cis-trans isomerase, 8-DEETHYL-8-[BUT-3-ENYL]-ASCOMYCIN, CALCIUM ION, ... (6 entities in total) |
Functional Keywords | ssgcid, isomerase, structural genomics, seattle structural genomics center for infectious disease |
Biological source | Burkholderia pseudomallei |
Total number of polymer chains | 2 |
Total formula weight | 26164.30 |
Authors | Seattle Structural Genomics Center for Infectious Disease (SSGCID) (deposition date: 2012-02-29, release date: 2012-03-28, Last modification date: 2023-09-13) |
Primary citation | Begley, D.W.,Fox, D.,Jenner, D.,Juli, C.,Pierce, P.G.,Abendroth, J.,Muruthi, M.,Safford, K.,Anderson, V.,Atkins, K.,Barnes, S.R.,Moen, S.O.,Raymond, A.C.,Stacy, R.,Myler, P.J.,Staker, B.L.,Harmer, N.J.,Norville, I.H.,Holzgrabe, U.,Sarkar-Tyson, M.,Edwards, T.E.,Lorimer, D.D. A structural biology approach enables the development of antimicrobials targeting bacterial immunophilins. Antimicrob.Agents Chemother., 58:1458-1467, 2014 Cited by PubMed: 24366729DOI: 10.1128/AAC.01875-13 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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