4DZ2

Crystal structure of a Peptidyl-prolyl cis-trans isomerase with surface mutation R92G from Burkholderia pseudomallei complexed with FK506

Summary for 4DZ2

Entry DOI	10.2210/pdb4dz2/pdb
Related	2ke0 2ko7 2l2s 3uf8 3uqa 3uqb 3vaw 4DZ3
Descriptor	Peptidyl-prolyl cis-trans isomerase, 8-DEETHYL-8-[BUT-3-ENYL]-ASCOMYCIN, CALCIUM ION, ... (4 entities in total)
Functional Keywords	ssgcid, isomerase, structural genomics, seattle structural genomics center for infectious disease
Biological source	Burkholderia pseudomallei
Total number of polymer chains	2
Total formula weight	25282.49
Authors	Seattle Structural Genomics Center for Infectious Disease (SSGCID) (deposition date: 2012-02-29, release date: 2012-03-28, Last modification date: 2023-09-13)
Primary citation	Begley, D.W.,Fox, D.,Jenner, D.,Juli, C.,Pierce, P.G.,Abendroth, J.,Muruthi, M.,Safford, K.,Anderson, V.,Atkins, K.,Barnes, S.R.,Moen, S.O.,Raymond, A.C.,Stacy, R.,Myler, P.J.,Staker, B.L.,Harmer, N.J.,Norville, I.H.,Holzgrabe, U.,Sarkar-Tyson, M.,Edwards, T.E.,Lorimer, D.D. A structural biology approach enables the development of antimicrobials targeting bacterial immunophilins. Antimicrob.Agents Chemother., 58:1458-1467, 2014 Cited by PubMed: 24366729 DOI: 10.1128/AAC.01875-13 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation