4DX0

Structure of the 14-3-3/PMA2 complex stabilized by a pyrazole derivative

Summary for 4DX0

• Entry DOI: 10.2210/pdb4dx0/pdb
• Related: 3M50 3M51
• Descriptor: 14-3-3-like protein E, N.plumbaginifolia H+-translocating ATPase mRNA, 4-[(4R)-4-(4-nitrophenyl)-6-oxidanylidene-3-phenyl-1,4-dihydropyrrolo[3,4-c]pyrazol-5-yl]benzoic acid (3 entities in total)
• Functional Keywords: 14-3-3 fold, pyrrolidinones, protein binding-hydrolase complex, protein binding/hydrolase
• Biological source: Nicotiana tabacum (American tobacco,tobacco); More
• Total number of polymer chains: 2
• Total formula weight: 31522.58

Authors

Richter, A.,Rose, R.,Hedberg, C.,Waldmann, H.,Ottmann, C. (deposition date: 2012-02-27, release date: 2012-05-30, Last modification date: 2023-12-13)

• Primary citation: Richter, A.,Rose, R.,Hedberg, C.,Waldmann, H.,Ottmann, C.; An Optimised Small-Molecule Stabiliser of the 14-3-3-PMA2 Protein-Protein Interaction.; Chemistry, 18:6520-6527, 2012; PubMed: 22467351; DOI: 10.1002/chem.201103761

Experimental method

X-RAY DIFFRACTION (3.4 Å)