4DUH
Crystal structure of 24 kDa domain of E. coli DNA gyrase B in complex with small molecule inhibitor
Summary for 4DUH
| Entry DOI | 10.2210/pdb4duh/pdb |
| Related | 1AJ6 1KZN |
| Descriptor | DNA gyrase subunit B, 4-{[4'-methyl-2'-(propanoylamino)-4,5'-bi-1,3-thiazol-2-yl]amino}benzoic acid (3 entities in total) |
| Functional Keywords | structure-based drug design, antibacterial, dna gyrase b, gyrase, isomerase-isomerase inhibitor complex, isomerase/isomerase inhibitor |
| Biological source | Escherichia coli |
| Cellular location | Cytoplasm (Potential): P0AES6 |
| Total number of polymer chains | 2 |
| Total formula weight | 49159.29 |
| Authors | Brvar, M.,Renko, M.,Perdih, A.,Solmajer, T.,Turk, D. (deposition date: 2012-02-22, release date: 2012-08-01, Last modification date: 2023-09-13) |
| Primary citation | Brvar, M.,Perdih, A.,Renko, M.,Anderluh, G.,Turk, D.,Solmajer, T. Structure-based discovery of substituted 4,5'-bithiazoles as novel DNA gyrase inhibitors. J.Med.Chem., 55:6413-6426, 2012 Cited by PubMed: 22731783DOI: 10.1021/jm300395d PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.5 Å) |
Structure validation
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