4DUH
Crystal structure of 24 kDa domain of E. coli DNA gyrase B in complex with small molecule inhibitor
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003677 | molecular_function | DNA binding |
| A | 0003918 | molecular_function | DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0006265 | biological_process | DNA topological change |
| B | 0003677 | molecular_function | DNA binding |
| B | 0003918 | molecular_function | DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0006265 | biological_process | DNA topological change |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE RLI A 301 |
| Chain | Residue |
| A | VAL43 |
| A | ARG136 |
| A | THR165 |
| A | HOH614 |
| A | HOH702 |
| A | ASN46 |
| A | GLU50 |
| A | ASP73 |
| A | ARG76 |
| A | ILE78 |
| A | PRO79 |
| A | GLY101 |
| A | LYS103 |
| site_id | AC2 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE RLI B 301 |
| Chain | Residue |
| B | VAL43 |
| B | ASN46 |
| B | GLU50 |
| B | VAL71 |
| B | ASP73 |
| B | ARG76 |
| B | ILE78 |
| B | PRO79 |
| B | ILE94 |
| B | GLY101 |
| B | ARG136 |
| B | THR165 |
| B | HOH451 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: Proton acceptor (ATPase activity) => ECO:0000305|PubMed:10734094, ECO:0000305|PubMed:8248233 |
| Chain | Residue | Details |
| A | GLU42 | |
| B | GLU42 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:25202966, ECO:0000269|PubMed:25849408, ECO:0000305|PubMed:10734094 |
| Chain | Residue | Details |
| A | TYR5 | |
| B | TYR5 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 10 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:10734094, ECO:0000269|PubMed:25202966, ECO:0000269|PubMed:25849408 |
| Chain | Residue | Details |
| A | ASN46 | |
| B | LEU115 | |
| A | ASP73 | |
| A | GLY102 | |
| A | TYR109 | |
| A | LEU115 | |
| B | ASN46 | |
| B | ASP73 | |
| B | GLY102 | |
| B | TYR109 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 14 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:25849408 |
| Chain | Residue | Details |
| A | ILE94 | |
| B | ALA100 | |
| B | LYS103 | |
| B | ASP105 | |
| B | GLY117 | |
| B | SER121 | |
| A | VAL97 | |
| A | ALA100 | |
| A | LYS103 | |
| A | ASP105 | |
| A | GLY117 | |
| A | SER121 | |
| B | ILE94 | |
| B | VAL97 |
