4DMN
HIV-1 Integrase Catalytical Core Domain
Summary for 4DMN
Entry DOI | 10.2210/pdb4dmn/pdb |
Related | 1ITG |
Descriptor | HIV-1 Integrase, ARSENIC, SULFATE ION, ... (5 entities in total) |
Functional Keywords | integrase, ccd, dde motif, dimer interface, viral protein-inhibitor complex, viral protein/inhibitor |
Biological source | Human immunodeficiency virus type 1 (HIV-1) |
Cellular location | Gag-Pol polyprotein: Host cell membrane; Lipid-anchor . Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P12497 |
Total number of polymer chains | 1 |
Total formula weight | 18675.13 |
Authors | Feng, L.,Kvaratskhelia, M. (deposition date: 2012-02-08, release date: 2012-03-21, Last modification date: 2024-02-28) |
Primary citation | Kessl, J.J.,Jena, N.,Koh, Y.,Taskent-Sezgin, H.,Slaughter, A.,Feng, L.,de Silva, S.,Wu, L.,Le Grice, S.F.,Engelman, A.,Fuchs, J.R.,Kvaratskhelia, M. Multimode, cooperative mechanism of action of allosteric HIV-1 integrase inhibitors. J.Biol.Chem., 287:16801-16811, 2012 Cited by PubMed: 22437836DOI: 10.1074/jbc.M112.354373 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.45 Å) |
Structure validation
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