4DMN

HIV-1 Integrase Catalytical Core Domain

Summary for 4DMN

• Entry DOI: 10.2210/pdb4dmn/pdb
• Related: 1ITG
• Descriptor: HIV-1 Integrase, ARSENIC, SULFATE ION, ... (5 entities in total)
• Functional Keywords: integrase, ccd, dde motif, dimer interface, viral protein-inhibitor complex, viral protein/inhibitor
• Biological source: Human immunodeficiency virus type 1 (HIV-1)
• Cellular location: Gag-Pol polyprotein: Host cell membrane; Lipid-anchor . Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P12497
• Total number of polymer chains: 1
• Total formula weight: 18675.13

Authors

Feng, L.,Kvaratskhelia, M. (deposition date: 2012-02-08, release date: 2012-03-21, Last modification date: 2024-02-28)

• Primary citation: Kessl, J.J.,Jena, N.,Koh, Y.,Taskent-Sezgin, H.,Slaughter, A.,Feng, L.,de Silva, S.,Wu, L.,Le Grice, S.F.,Engelman, A.,Fuchs, J.R.,Kvaratskhelia, M.; Multimode, cooperative mechanism of action of allosteric HIV-1 integrase inhibitors.; J.Biol.Chem., 287:16801-16811, 2012; PubMed: 22437836; DOI: 10.1074/jbc.M112.354373

Experimental method

X-RAY DIFFRACTION (2.45 Å)