4DMA
Crystal structure of ERa LBD in complex with RU100132
Summary for 4DMA
Entry DOI | 10.2210/pdb4dma/pdb |
Related | 1G50 4DM6 4DM8 |
Descriptor | Estrogen receptor, Nuclear receptor coactivator 1, 2'-bromo-6'-(furan-3-yl)-4'-(hydroxymethyl)biphenyl-4-ol, ... (4 entities in total) |
Functional Keywords | transcription, nuclear receptor, er, estrogen receptor, alpha helical sandwich, transcription factor, estradiol, transcription-protein binding-agonist complex, transcription/protein binding/agonist |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 4 |
Total formula weight | 60709.04 |
Authors | Osz, J.,Brelivet, Y.,Peluso-Iltis, C.,Cura, V.,Eiler, S.,Ruff, M.,Bourguet, W.,Rochel, N.,Moras, D. (deposition date: 2012-02-07, release date: 2012-03-07, Last modification date: 2024-02-28) |
Primary citation | Osz, J.,Brelivet, Y.,Peluso-Iltis, C.,Cura, V.,Eiler, S.,Ruff, M.,Bourguet, W.,Rochel, N.,Moras, D. Structural basis for a molecular allosteric control mechanism of cofactor binding to nuclear receptors. Proc.Natl.Acad.Sci.USA, 109:E588-E594, 2012 Cited by PubMed: 22355136DOI: 10.1073/pnas.1118192109 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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