4DMA
Crystal structure of ERa LBD in complex with RU100132
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Estrogen receptor | polymer | 247 | 28233.3 | 2 | UniProt (P03372) Pfam (PF00104) | Homo sapiens (human) | ER, ER-alpha, Estradiol receptor, Nuclear receptor subfamily 3 group A member 1 |
| 2 | C, D (E, F) | Nuclear receptor coactivator 1 | polymer | 15 | 1776.1 | 2 | UniProt (P70365) | Mus musculus | NCoA-1, Nuclear receptor coactivator protein 1, mNRC-1, Steroid receptor coactivator 1, SRC-1 |
| 3 | E, F (A, B) | 2'-bromo-6'-(furan-3-yl)-4'-(hydroxymethyl)biphenyl-4-ol | non-polymer | 345.2 | 2 | Chemie (0L8) | |||
| 4 | G, H, I, J (A, B, E, F) | water | water | 18.0 | 120 | Chemie (HOH) |
Sequence modifications
A, B: 303 - 549 (UniProt: P03372)
| PDB | External Database | Details |
|---|---|---|
| Ala 530 | Cys 530 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 60018.7 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 690.4 | |
| All* | Total formula weight | 60709.0 |
