4DMA
Crystal structure of ERa LBD in complex with RU100132
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE 0L8 A 701 |
| Chain | Residue |
| A | MET343 |
| A | LEU540 |
| A | HOH845 |
| A | ALA350 |
| A | GLU353 |
| A | TRP383 |
| A | LEU384 |
| A | ARG394 |
| A | LEU428 |
| A | GLY521 |
| A | HIS524 |
| site_id | AC2 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE 0L8 B 1701 |
| Chain | Residue |
| B | THR1347 |
| B | ALA1350 |
| B | GLU1353 |
| B | LEU1387 |
| B | MET1421 |
| B | LEU1428 |
| B | HIS1524 |
| B | LEU1525 |
| B | LEU1540 |
| B | HOH1804 |
| site_id | AC3 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR CHAIN E OF NUCLEAR RECEPTOR COACTIVATOR 1 |
| Chain | Residue |
| A | ILE358 |
| A | LYS362 |
| A | LEU372 |
| A | GLN375 |
| A | VAL376 |
| A | GLU380 |
| A | ASP538 |
| A | GLU542 |
| A | MET543 |
| B | TYR1331 |
| B | PRO1333 |
| E | HOH801 |
| E | HOH804 |
| E | HOH806 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"9338790","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9600906","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1A52","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1ERE","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphotyrosine; by Tyr-kinases","evidences":[{"source":"PubMed","id":"7539106","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Lipidation: {"description":"S-palmitoyl cysteine","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 8 |
| Details | Motif: {"description":"LXXLL motif 4"} |
| Chain | Residue | Details |
