4DKD
Crystal Structure of Human Interleukin-34 Bound to Human CSF-1R
Summary for 4DKD
Entry DOI | 10.2210/pdb4dkd/pdb |
Descriptor | Interleukin-34, Macrophage colony-stimulating factor 1 receptor, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total) |
Functional Keywords | dimeric four-helix bundle cytokine, receptor tyrosine kinase, glycosylation, cytokine-transferase complex, cytokine/transferase |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 3 |
Total formula weight | 77006.20 |
Authors | Ma, X.,Bazan, J.F.,Starovasnik, M.A. (deposition date: 2012-02-03, release date: 2012-04-11, Last modification date: 2020-07-29) |
Primary citation | Ma, X.,Lin, W.Y.,Chen, Y.,Stawicki, S.,Mukhyala, K.,Wu, Y.,Martin, F.,Bazan, J.F.,Starovasnik, M.A. Structural Basis for the Dual Recognition of Helical Cytokines IL-34 and CSF-1 by CSF-1R. Structure, 20:676-687, 2012 Cited by PubMed: 22483114DOI: 10.1016/j.str.2012.02.010 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3 Å) |
Structure validation
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