4CTO
Glucopyranosylidene-spiro-iminothiazolidinone, a New Bicyclic Ring System: Synthesis, Derivatization, and Evaluation as Glycogen Phosphorylase Inhibitors by Enzyme Kinetic and Crystallographic Methods
Summary for 4CTO
Entry DOI | 10.2210/pdb4cto/pdb |
Related | 4CTM 4CTN |
Descriptor | GLYCOGEN PHOSPHORYLASE, MUSCLE FORM, N-[(2Z,5R,7R,8S,9S,10R)-8,9,10-trihydroxy-7-(hydroxymethyl)-4-oxo-6-oxa-1-thia-3-azaspiro[4.5]dec-2-ylidene]benzamide, PYRIDOXAL-5'-PHOSPHATE, ... (5 entities in total) |
Functional Keywords | transferase, type 2 diabetes, inhibitor, structure-based drug design |
Biological source | ORYCTOLAGUS CUNICULUS (RABBIT) |
Total number of polymer chains | 1 |
Total formula weight | 98132.87 |
Authors | Alexacou, K.M.,Papakonstantinou, M.,Leonidas, D.D.,Zographos, S.E.,Chrysina, E.D. (deposition date: 2014-03-15, release date: 2014-08-06, Last modification date: 2023-12-20) |
Primary citation | Czifrak, K.,Deak, S.,Pahi, A.,Kover, K.E.,Docsa, T.,Gergely, P.,Alexacou, K.M.,Papakonstantinou, M.,Leonidas, D.D.,Zographos, S.E.,Chrysina, E.D.,Somsak, L. Glucopyranosylidene-Spiro-Iminothiazolidinone, a New Bicyclic Ring System: Synthesis, Derivatization, and Evaluation for Inhibition of Glycogen Phosphorylase by Enzyme Kinetic and Crystallographic Methods. Bioorg.Med.Chem., 22:4028-, 2014 Cited by PubMed: 25009003DOI: 10.1016/J.BMC.2014.05.076 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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