4CGZ

Crystal structure of the Bloom's syndrome helicase BLM in complex with DNA

Summary for 4CGZ

• Entry DOI: 10.2210/pdb4cgz/pdb
• Descriptor: BLOOM'S SYNDROME HELICASE, 5'-D(*AP*GP*CP*GP*TP*CP*GP*AP*GP*AP*TP*CP)-3', 5'-D(*GP*AP*TP*CP*TP*CP*GP*AP*CP*GP*CP*TP*CP*DT *CP*CP*CP)-3', ... (5 entities in total)
• Functional Keywords: hydrolase-dna complex, hydrolase/dna
• Biological source: HOMO SAPIENS (HUMAN); More
• Cellular location: Nucleus : P54132
• Total number of polymer chains: 3
• Total formula weight: 84971.42

Authors

Newman, J.A.,Savitsky, P.,Krojer, T.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.,Bountra, C.,Gileadi, O. (deposition date: 2013-11-27, release date: 2013-12-11, Last modification date: 2023-12-20)

• Primary citation: Newman, J.A.,Savitsky, P.,Allerston, C.K.,Bizard, A.H.,Ozer, O.,Sarlos, K.,Liu, Y.,Pardon, E.,Steyaert, J.,Hickson, I.D.,Gileadi, O.; Crystal Structure of the Bloom'S Syndrome Helicase Indicates a Role for the Hrdc Domain in Conformational Changes.; Nucleic Acids Res., 43:5221-, 2015; PubMed: 25901030; DOI: 10.1093/NAR/GKV373

Experimental method

X-RAY DIFFRACTION (3.2 Å)