4BYH

Crystal structure of sialylated IgG Fc

Summary for 4BYH

• Entry DOI: 10.2210/pdb4byh/pdb
• Descriptor: IG GAMMA-1 CHAIN C REGION, N-acetyl-alpha-neuraminic acid-(2-6)-beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
• Functional Keywords: immune system, antibody, sialyation, immunoglobulin
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 56486.86

Authors

Crispin, M.,Yu, X.,Bowden, T.A. (deposition date: 2013-07-19, release date: 2013-08-21, Last modification date: 2023-12-20)

• Primary citation: Crispin, M.,Yu, X.,Bowden, T.A.; Crystal Structure of Sialylated Igg Fc: Implications for the Mechanism of Intravenous Immunoglobulin Therapy.; Proc.Natl.Acad.Sci.USA, 110:E3544-, 2013; PubMed: 23929778; DOI: 10.1073/PNAS.1310657110

Experimental method

X-RAY DIFFRACTION (2.3 Å)