4BYH

Crystal structure of sialylated IgG Fc

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	IG GAMMA-1 CHAIN C REGION	polymer	233	26355.8	2	UniProt (P01857) Pfam (PF07654)	Homo sapiens (Human)	IGG FC
2	C (C)	N-acetyl-alpha-neuraminic acid-(2-6)-beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose	branched		1916.7	1	In PDB GlyTouCan (G23295TF)
3	D (D)	beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose	branched		1787.6	1	In PDB GlyTouCan (G78059CC)
4	E, F (A, B)	CHLORIDE ION	non-polymer		35.5	2	Chemie (CL)
5	G, H (A, B)	water	water		18.0	166	Chemie (HOH)

Sequence modifications

A, B: 223 - 446 (UniProt: P01857)

PDB	External Database	Details
Gly 222	-	expression tag
Glu 356	Asp 239	conflict
Met 358	Leu 241	conflict
Thr 447	-	expression tag
Lys 448	-	expression tag
His 449	-	expression tag
His 450	-	expression tag
His 451	-	expression tag
His 452	-	expression tag
His 453	-	expression tag
His 454	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	52711.6
Branched	Number of molecules	2
	Total formula weight	3704.4
Non-Polymers*	Number of molecules	2
	Total formula weight	70.9
All*	Total formula weight	56486.9

*Water molecules are not included.