4BJC

Crystal structure of human tankyrase 2 in complex with Rucaparib

Summary for 4BJC

Entry DOI	10.2210/pdb4bjc/pdb
Related	4BJ9 4BJB
Descriptor	TANKYRASE-2, Rucaparib, SULFATE ION, ... (5 entities in total)
Functional Keywords	transferase, protein-ligand complex, diphtheria toxin like fold, adp- ribosylation, transferase inhibitor complex
Biological source	HOMO SAPIENS (HUMAN)
Cellular location	Cytoplasm: Q9H2K2
Total number of polymer chains	1
Total formula weight	27880.66
Authors	Haikarainen, T.,Narwal, M.,Lehtio, L. (deposition date: 2013-04-18, release date: 2013-12-11, Last modification date: 2024-05-08)
Primary citation	Haikarainen, T.,Narwal, M.,Joensuu, P.,Lehtio, L. Evaluation and Structural Basis for the Inhibition of Tankyrases by Parp Inhibitors Acs Med.Chem.Lett., 5:18-, 2014 Cited by PubMed: 24900770 DOI: 10.1021/ML400292S PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation