4BJC

Crystal structure of human tankyrase 2 in complex with Rucaparib

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	TANKYRASE-2	polymer	240	27299.8	1	UniProt (Q9H2K2) Pfam (PF00644) In PDB	HOMO SAPIENS (HUMAN)	TANK2, ADP-RIBOSYLTRANSFERASE DIPHTHERIA TOXIN-LIKE 6, ARTD6, POLY [ADP-RIBOSE] POLYMERASE 5B, TNKS-2, TRF1-INTERACTING ANKYRIN-RELATED ADP-RIBOSE POLYMERASE 2, TANKYRASE II, TANKYRASE-LIKE PROTEIN, TANKYRASE-RELATED PROTEIN
2	A	Rucaparib	non-polymer		323.4	1	Chemie (RPB)
3	A	SULFATE ION	non-polymer		96.1	2	Chemie (SO4)
4	A	ZINC ION	non-polymer		65.4	1	Chemie (ZN)
5		water	water		18.0	89	Chemie (HOH)

Sequence modifications

A: 946 - 1162 (UniProt: Q9H2K2)

PDB	External Database	Details
Met 923	-	expression tag
His 924	-	expression tag
His 925	-	expression tag
His 926	-	expression tag
His 927	-	expression tag
His 928	-	expression tag
His 929	-	expression tag
Ser 930	-	expression tag
Ser 931	-	expression tag
Gly 932	-	expression tag
Val 933	-	expression tag
Asp 934	-	expression tag
Leu 935	-	expression tag
Gly 936	-	expression tag
Thr 937	-	expression tag
Glu 938	-	expression tag
Asn 939	-	expression tag
Leu 940	-	expression tag
Tyr 941	-	expression tag
Phe 942	-	expression tag
Gln 943	-	expression tag
Ser 944	-	expression tag
Met 945	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	27299.8
Non-Polymers*	Number of molecules	4
	Total formula weight	580.9
All*	Total formula weight	27880.7

*Water molecules are not included.