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4BD2

Bax domain swapped dimer in complex with BidBH3

Summary for 4BD2
Entry DOI10.2210/pdb4bd2/pdb
Related4BD6 4BD7 4BD8 4BDU
DescriptorAPOPTOSIS REGULATOR BAX, BH3-INTERACTING DOMAIN DEATH AGONIST (3 entities in total)
Functional Keywordsapoptosis, programmed cell death, bcl-2 family.
Biological sourceHOMO SAPIENS (HUMAN)
More
Cellular locationIsoform Alpha: Mitochondrion membrane; Single-pass membrane protein. Isoform Beta: Cytoplasm. Isoform Gamma: Cytoplasm. Isoform Delta: Cytoplasm (Potential): Q07812
Cytoplasm (By similarity). BH3-interacting domain death agonist p15: Mitochondrion membrane (By similarity). BH3-interacting domain death agonist p13: Mitochondrion membrane (By similarity). Isoform 1: Cytoplasm. Isoform 3: Cytoplasm. Isoform 2: Mitochondrion membrane: P55957
Total number of polymer chains2
Total formula weight22875.82
Authors
Czabotar, P.E.,Westphal, D.,Adams, J.M.,Colman, P.M. (deposition date: 2012-10-04, release date: 2013-02-13)
Primary citationCzabotar, P.E.,Westphal, D.,Dewson, G.,Ma, S.,Hockings, C.,Fairlie, W.D.,Lee, E.F.,Yao, S.,Robin, A.Y.,Smith, B.J.,Huang, D.C.,Kluck, R.M.,Adams, J.M.,Colman, P.M.
Bax Crystal Structures Reveal How Bh3 Domains Activate Bax and Nucleate its Oligomerization to Induce Apoptosis.
Cell(Cambridge,Mass.), 152:519-, 2013
Cited by
PubMed: 23374347
DOI: 10.1016/J.CELL.2012.12.031
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.206 Å)
Structure validation

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