4BD2
Bax domain swapped dimer in complex with BidBH3
Summary for 4BD2
Entry DOI | 10.2210/pdb4bd2/pdb |
Related | 4BD6 4BD7 4BD8 4BDU |
Descriptor | APOPTOSIS REGULATOR BAX, BH3-INTERACTING DOMAIN DEATH AGONIST (3 entities in total) |
Functional Keywords | apoptosis, programmed cell death, bcl-2 family. |
Biological source | HOMO SAPIENS (HUMAN) More |
Cellular location | Isoform Alpha: Mitochondrion membrane; Single-pass membrane protein. Isoform Beta: Cytoplasm. Isoform Gamma: Cytoplasm. Isoform Delta: Cytoplasm (Potential): Q07812 Cytoplasm (By similarity). BH3-interacting domain death agonist p15: Mitochondrion membrane (By similarity). BH3-interacting domain death agonist p13: Mitochondrion membrane (By similarity). Isoform 1: Cytoplasm. Isoform 3: Cytoplasm. Isoform 2: Mitochondrion membrane: P55957 |
Total number of polymer chains | 2 |
Total formula weight | 22875.82 |
Authors | Czabotar, P.E.,Westphal, D.,Adams, J.M.,Colman, P.M. (deposition date: 2012-10-04, release date: 2013-02-13, Last modification date: 2024-05-01) |
Primary citation | Czabotar, P.E.,Westphal, D.,Dewson, G.,Ma, S.,Hockings, C.,Fairlie, W.D.,Lee, E.F.,Yao, S.,Robin, A.Y.,Smith, B.J.,Huang, D.C.,Kluck, R.M.,Adams, J.M.,Colman, P.M. Bax Crystal Structures Reveal How Bh3 Domains Activate Bax and Nucleate its Oligomerization to Induce Apoptosis. Cell(Cambridge,Mass.), 152:519-, 2013 Cited by PubMed: 23374347DOI: 10.1016/J.CELL.2012.12.031 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.206 Å) |
Structure validation
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