4BCN

Structure of CDK2 in complex with cyclin A and a 2-amino-4-heteroaryl- pyrimidine inhibitor

Summary for 4BCN

Entry DOI	10.2210/pdb4bcn/pdb
Related	4BCF 4BCG 4BCH 4BCI 4BCJ 4BCK 4BCM 4BCO 4BCP 4BCQ
Descriptor	CYCLIN-DEPENDENT KINASE 2, CYCLIN-A2, 2-[(3-hydroxyphenyl)amino]-4-[4-methyl-2-(methylamino)-1,3-thiazol-5-yl]pyrimidine-5-carbonitrile, ... (6 entities in total)
Functional Keywords	transferase-cell cycle complex, cdk-cyclin complex, cyclin-inhibitor, structure-based drug design, transferase/cell cycle
Biological source	HOMO SAPIENS (HUMAN) More
Cellular location	Cytoplasm, cytoskeleton, centrosome: P24941 Nucleus: P20248 P20248
Total number of polymer chains	4
Total formula weight	129384.56
Authors	Hole, A.J.,Baumli, S.,Wang, S.,Endicott, J.A.,Noble, M.E.M. (deposition date: 2012-10-02, release date: 2013-03-06)
Primary citation	Hole, A.J.,Baumli, S.,Shao, H.,Shi, S.,Pepper, C.,Fischer, P.M.,Wang, S.,Endicott, J.A.,Noble, M.E.M. Comparative Structural and Functional Studies of 4-(Thiazol- 5-Yl)-2-(Phenylamino)Pyrimidine-5-Carbonitrile Cdk9 Inhibitors Suggest the Basis for Isotype Selectivity. J.Med.Chem., 56:660-, 2013 Cited by PubMed: 23252711 DOI: 10.1021/JM301495V PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation