4AG8
CRYSTAL STRUCTURE OF THE VEGFR2 KINASE DOMAIN IN COMPLEX WITH AXITINIB (AG-013736) (N-Methyl-2-(3-((E)-2-pyridin-2-yl-vinyl)-1H- indazol-6-ylsulfanyl)-benzamide)
Summary for 4AG8
Entry DOI | 10.2210/pdb4ag8/pdb |
Related | 1VR2 1Y6A 1Y6B 1YWN 2X1W 2X1X 2XIR 4AGC 4AGD 4ASD 4ASE |
Descriptor | VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2, AXITINIB (3 entities in total) |
Functional Keywords | transferase, angiogenesis, nucleotide-binding, inhibitor, phosphorylation, transmembrane |
Biological source | HOMO SAPIENS (HUMAN) |
Total number of polymer chains | 1 |
Total formula weight | 36581.23 |
Authors | McTigue, M.,Wickersham, J.,Pinko, C.,Kania, R.S.,Bender, S. (deposition date: 2012-01-24, release date: 2012-09-26, Last modification date: 2024-08-07) |
Primary citation | Mctigue, M.,Murray, B.W.,Chen, J.H.,Deng, Y.,Solowiej, J.,Kania, R.S. Molecular Conformations, Interactions, and Properties Associated with Drug Efficiency and Clinical Performance Among Vegfr Tk Inhibitors. Proc.Natl.Acad.Sci.USA, 109:18281-, 2012 Cited by PubMed: 22988103DOI: 10.1073/PNAS.1207759109 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.95 Å) |
Structure validation
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