2XIR
Crystal structure of the VEGFR2 kinase domain in complex with PF- 00337210 (N,2-dimethyl-6-(7-(2-morpholinoethoxy)quinolin-4-yloxy) benzofuran-3-carboxamide)
Summary for 2XIR
Entry DOI | 10.2210/pdb2xir/pdb |
Related | 1VR2 1Y6A 1Y6B 1YWN 2X1W 2X1X |
Descriptor | VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2, N,2-DIMETHYL-6-{[7-(2-MORPHOLIN-4-YLETHOXY)QUINOLIN-4-YL]OXY}-1-BENZOFURAN-3-CARBOXAMIDE (3 entities in total) |
Functional Keywords | angiogenesis, nucleotide-binding, inhibitor, phosphorylation, receptor, transferase, transmembrane |
Biological source | HOMO SAPIENS (HUMAN) |
Total number of polymer chains | 1 |
Total formula weight | 36656.27 |
Authors | McTigue, M.,Wickersham, J.,Pinko, C.,Hong, Y.,Marrone, T. (deposition date: 2010-06-30, release date: 2011-04-13, Last modification date: 2023-12-20) |
Primary citation | Mctigue, M.,Wickersham, J.,Marrone, T. Discovery of the Selective Vegfr Inhibitor Pf- 00337210 To be Published, |
Experimental method | X-RAY DIFFRACTION (1.5 Å) |
Structure validation
Download full validation report