2XIR
Crystal structure of the VEGFR2 kinase domain in complex with PF- 00337210 (N,2-dimethyl-6-(7-(2-morpholinoethoxy)quinolin-4-yloxy) benzofuran-3-carboxamide)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2 | polymer | 316 | 36194.8 | 1 | UniProt (P35968) Pfam (PF07714) | HOMO SAPIENS | VEGFR-2, KINASE INSERT DOMAIN RECEPTOR, PROTEIN-TYROSINE KINASE RECEPTOR FLK-1, FETAL LIVER KINASE 1, FLK-1, CD309 |
| 2 | B (A) | N,2-DIMETHYL-6-{[7-(2-MORPHOLIN-4-YLETHOXY)QUINOLIN-4-YL]OXY}-1-BENZOFURAN-3-CARBOXAMIDE | non-polymer | 461.5 | 1 | Chemie (00J) | |||
| 3 | C (A) | water | water | 18.0 | 337 | Chemie (HOH) |
Sequence modifications
A: 990 - 1171 (UniProt: P35968)
| PDB | External Database | Details |
|---|---|---|
| Val 990 | Glu 990 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 36194.8 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 461.5 | |
| All* | Total formula weight | 36656.3 |
