4A9K

BROMODOMAIN OF HUMAN CREBBP WITH N-(4-hydroxyphenyl)acetamide

Summary for 4A9K

Entry DOI	10.2210/pdb4a9k/pdb
Related	1JSP 1LIQ 1WO3 1WO4 1WO5 1WO6 1WO7 2D82
Descriptor	CREB-BINDING PROTEIN, 1,2-ETHANEDIOL, N-(4-HYDROXYPHENYL)ACETAMIDE (TYLENOL), ... (6 entities in total)
Functional Keywords	inhibitor, histone, epigenetic reader, signaling protein
Biological source	HOMO SAPIENS (HUMAN)
Total number of polymer chains	2
Total formula weight	28970.34
Authors	Chung, C.W.,Bamborough, P. (deposition date: 2011-11-26, release date: 2012-01-11, Last modification date: 2019-04-03)
Primary citation	Chung, C.W.,Dean, A.W.,Woolven, J.M.,Bamborough, P. Fragment-Based Discovery of Bromodomain Inhibitors Part 1: Inhibitor Binding Modes and Implications for Lead Discovery. J.Med.Chem., 55:576-, 2012 Cited by PubMed: 22136404 DOI: 10.1021/JM201320W PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.81 Å)

Structure validation