4A6C
Stereoselective Synthesis, X-ray Analysis, and Biological Evaluation of a New Class of Lactam Based HIV-1 Protease Inhibitors
Summary for 4A6C
Entry DOI | 10.2210/pdb4a6c/pdb |
Related | 1GNO 1WBK 1WBM 1ZPA 2CEJ 2CEM 4A4Q |
Descriptor | POL PROTEIN, METHYL ((S)-1-(2-(3-((3S,4S)-3-BENZYL-4-HYDROXY-1-((1S,2R)-2-HYDROXY-2,3-DIHYDRO-1H-INDEN-1-YL)-2-OXOPYRROLIDIN-3-YL)PROPYL)-2-(4-(PYRIDIN-4-YL)BENZYL)HYDRAZINYL)-3,3-DIMETHYL-1-OXOBUTAN-2-YL)CARBAMATE (3 entities in total) |
Functional Keywords | hydrolase, gamma-butyrol-lactam |
Biological source | HUMAN IMMUNODEFICIENCY VIRUS |
Total number of polymer chains | 2 |
Total formula weight | 22285.21 |
Authors | Wu, X.,Ohrngren, P.,Joshi, A.A.,Trejos, A.,Persson, M.,Unge, J.,Arvela, R.K.,Wallberg, H.,Vrang, L.,Rosenquist, A.,Samuelsson, B.B.,Unge, J.,Larhed, M. (deposition date: 2011-11-01, release date: 2012-05-09, Last modification date: 2024-05-01) |
Primary citation | Wu, X.,Ohrngren, P.,Joshi, A.A.,Trejos, A.,Persson, M.,Arvela, R.K.,Wallberg, H.,Vrang, L.,Rosenquist, A.,Samuelsson, B.B.,Unge, J.,Larhed, M. Synthesis, X-Ray Analysis, and Biological Evaluation of a New Class of Stereopure Lactam-Based HIV-1 Protease Inhibitors. J.Med.Chem., 55:2724-, 2012 Cited by PubMed: 22376008DOI: 10.1021/JM201620T PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.5 Å) |
Structure validation
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