2CEM

P1' Extended HIV-1 Protease Inhibitors Encompassing a Tertiary Alcohol in the Transition-State Mimicking Scaffold

Summary for 2CEM

Entry DOI	10.2210/pdb2cem/pdb
Related	1WBK 1WBM 2CEJ 2CEN
Descriptor	POL PROTEIN, {(1S)-1-[N'-[(2S)-2-HYDROXY-2-((1S,2R)-2-HYDROXY-INDAN-1-YLCARBAMOYL)-3-PHENYL-PROPYL]-N'-[4-(PYRIDINE-2-YL)-BENZYL]-HYDRAZINOCARBONYL]-2,2-DIMETHYL-PROPYL}-CARBAMIC ACID METHYL ESTER (3 entities in total)
Functional Keywords	hiv-1, protease, inhibitor, aspartyl protease, hydrolase
Biological source	HUMAN IMMUNODEFICIENCY VIRUS 1
Total number of polymer chains	2
Total formula weight	22287.32
Authors	Ginman, N.,Ekegren, J.K.,Johansson, A.,Wallberg, H.,Larhed, M.,Samuelsson, B.,Hallberg, A.,Unge, T. (deposition date: 2006-02-08, release date: 2007-02-13, Last modification date: 2023-12-13)
Primary citation	Ekegren, J.K.,Ginman, N.,Johansson, A.,Wallberg, H.,Larhed, M.,Samuelsson, B.,Unge, T.,Hallberg, A. Microwave-Accelerated Synthesis of P1'-Extended HIV-1 Protease Inhibitors Encompassing a Tertiary Alcohol in the Transition-State Mimicking Scaffold. J.Med.Chem., 49:1828-, 2006 Cited by PubMed: 16509598 DOI: 10.1021/JM051239Z PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation