Crystal structure of the light-activated constitutively active N2C, M257Y,D282C rhodopsin mutant in complex with a peptide resembling the C-terminus of the Galpha-protein subunit (GaCT)

Summary for 4A4M
Related1BOJ 1BOK 1EDS 1EDV 1EDW 1EDX 1F88 1FDF 1GZM 1HZX 1JFP 1L9H 1LN6 1N3M 1NZS 1OV0 1OV1 1U19 1VQX 2I35 2I36 2I37 2J4Y 2X72
DescriptorRHODOPSIN, GUANINE NUCLEOTIDE-BINDING PROTEIN G(T) SUBUNIT ALPHA-3, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (8 entities in total)
Functional Keywordssignaling protein, g-protein, g-protein-coupled receptors, signal tansduction, visual system, metarhodopsin-ii
Biological sourceBOS TAURUS (BOVINE)
Total number of polymer chains2
Total formula weight41648.74
Deupi, X.,Edwards, P.,Singhal, A.,Nickle, B.,Oprian, D.D.,Schertler, G.F.X.,Standfuss, J. (deposition date: 2011-10-17, release date: 2012-01-25, Last modification date: 2020-07-29)
Primary citationDeupi, X.,Edwards, P.,Nickle, B.,Oprian, D.,Schertler, G.,Singhal, A.,Standfuss, J.
Stabilized G Protein Binding Site in the Structure of Constitutively Active Metarhodopsin-II.
Proc.Natl.Acad.Sci.USA, 109:119-, 2012
PubMed: 22198838
DOI: 110.1073/PNAS.1114089108
PDB entries with the same primary citation
Experimental method
Structure validation
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PDB entries from 2021-06-23