3ZPG

Acinetobacter baumannii RibD, form 2

Summary for 3ZPG

• Entry DOI: 10.2210/pdb3zpg/pdb
• Related: 3ZPC
• Descriptor: RIBD, ZINC ION, SULFATE ION, ... (9 entities in total)
• Functional Keywords: reductase, deaminase, hydrolase
• Biological source: ACINETOBACTER BAUMANNII
• Total number of polymer chains: 1
• Total formula weight: 43478.79

Authors

Dawson, A.,Trumper, P.,Chrysostomou, G.,Hunter, W.N. (deposition date: 2013-02-27, release date: 2013-03-27, Last modification date: 2023-12-20)

Primary citation

Dawson, A.,Trumper, P.,Chrysostomou, G.,Hunter, W.N.
Structure of Diaminohydroxyphosphoribosylaminopyrimidine Deaminase/5-Amino-6-(5-Phosphoribosylamino)Uracil Reductase from Acinetobacter Baumannii.
Acta Crystallogr.,Sect.F, 69:611-, 2013

PubMed Abstract: The bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase (RibD) represents a potential antibacterial drug target. The structure of recombinant Acinetobacter baumannii RibD is reported in orthorhombic and tetragonal crystal forms at 2.2 and 2.0 Å resolution, respectively. Comparisons with orthologous structures in the Protein Data Bank indicated close similarities. The tetragonal crystal form was obtained in the presence of guanosine monophosphate, which surprisingly was observed to occupy the adenine-binding site of the reductase domain.

PubMed: 23722836
DOI: 10.1107/S174430911301292X

Experimental method

X-RAY DIFFRACTION (1.99 Å)