3ZMM
Inhibitors of Jak2 Kinase domain
Summary for 3ZMM
Entry DOI | 10.2210/pdb3zmm/pdb |
Descriptor | TYROSINE-PROTEIN KINASE JAK2, 5-FLUORO-4-[(1S)-1-(5-FLUOROPYRIMIDIN-2-YL)ETHOXY]-N-(5-METHYL-1H-PYRAZOL-3-YL)-6-MORPHOLINO-PYRIMIDIN-2-AMINE, ACETYL GROUP, ... (4 entities in total) |
Functional Keywords | transferase |
Biological source | HOMO SAPIENS (HUMAN) |
Cellular location | Endomembrane system ; Peripheral membrane protein : O60674 |
Total number of polymer chains | 2 |
Total formula weight | 71160.59 |
Authors | Read, J.,Green, I.,Pollard, H.,Howard, T.,Mott, R. (deposition date: 2013-02-11, release date: 2013-04-17, Last modification date: 2023-12-20) |
Primary citation | Guan, H.,Lamb, M.L.,Peng, B.,Huang, S.,Degrace, N.,Read, J.,Hussain, S.,Wu, J.,Rivard, C.,Alimzhanov, M.,Bebernitz, G.,Bell, K.,Ye, M.,Zinda, M.,Ioannidis, S. Discovery of Novel Jak2-Stat Pathway Inhibitors with Extended Residence Time on Target. Bioorg.Med.Chem.Lett., 23:3105-, 2013 Cited by PubMed: 23562594DOI: 10.1016/J.BMCL.2013.02.111 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.51 Å) |
Structure validation
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