3ZMM
Inhibitors of Jak2 Kinase domain
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | TYROSINE-PROTEIN KINASE JAK2 | polymer | 298 | 35095.8 | 2 | UniProt (O60674) Pfam (PF07714) | HOMO SAPIENS (HUMAN) | JANUS KINASE 2, JAK-2 |
| 2 | C, F (A, B) | 5-FLUORO-4-[(1S)-1-(5-FLUOROPYRIMIDIN-2-YL)ETHOXY]-N-(5-METHYL-1H-PYRAZOL-3-YL)-6-MORPHOLINO-PYRIMIDIN-2-AMINE | non-polymer | 418.4 | 2 | Chemie (F9J) | |||
| 3 | D, E, G (A, B) | ACETYL GROUP | non-polymer | 44.1 | 3 | Chemie (ACE) | |||
| 4 | H, I (A, B) | water | water | 18.0 | 140 | Chemie (HOH) |
Sequence modifications
A, B: 835 - 1132 (UniProt: O60674)
| PDB | External Database | Details |
|---|---|---|
| Ala 943 | Lys 943 | engineered mutation |
| Ala 945 | Lys 945 | engineered mutation |
| Gln 1129 | Asn 1129 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 70191.6 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 969.0 | |
| All* | Total formula weight | 71160.6 |
