3ZLU

Crystal structure of mouse acetylcholinesterase in complex with cyclosarin

Summary for 3ZLU

• Entry DOI: 10.2210/pdb3zlu/pdb
• Related: 3ZLT 3ZLV
• Descriptor: ACETYLCHOLINESTERASE, (2-hydroxyethoxy)acetaldehyde, 2,5,8,11,14,17-HEXAOXANONADECAN-19-OL, ... (4 entities in total)
• Functional Keywords: hydrolase, russian vx, cyclosarin, gf, tabun, ga, hi-6, oxime
• Biological source: MUS MUSCULUS (HOUSE MOUSE)
• Cellular location: Cell junction, synapse. Isoform H: Cell membrane; Lipid-anchor, GPI- anchor; Extracellular side: P21836
• Total number of polymer chains: 2
• Total formula weight: 120666.16

Authors

Artursson, E.,Andersson, P.O.,Akfur, C.,Linusson, A.,Borjegren, S.,Ekstrom, F. (deposition date: 2013-02-04, release date: 2013-03-27, Last modification date: 2023-12-20)

• Primary citation: Artursson, E.,Andersson, P.O.,Akfur, C.,Linusson, A.,Borjegren, S.,Ekstrom, F.; Catalytic-Site Conformational Equilibrium in Nerve-Agent Adducts of Acetylcholinesterase; Possible Implications for the Hi-6 Antidote Substrate Specificity.; Biochem.Pharmacol., 85:1389-, 2013; PubMed: 23376121; DOI: 10.1016/J.BCP.2013.01.016

Experimental method

X-RAY DIFFRACTION (2.6 Å)