3ZJ8

Crystal structure of strictosidine glucosidase in complex with inhibitor-2

Summary for 3ZJ8

• Entry DOI: 10.2210/pdb3zj8/pdb
• Related: 3ZJ6 3ZJ7
• Descriptor: STRICTOSIDINE-O-BETA-D-GLUCOSIDASE, (1R,2S,3S,4R,5R)-4-[(4-bromophenyl)methylamino]-5-(hydroxymethyl)cyclopentane-1,2,3-triol (3 entities in total)
• Functional Keywords: hydrolase, alkaloid, inhibitor
• Biological source: RAUVOLFIA SERPENTINA (SERPENTWOOD)
• Total number of polymer chains: 2
• Total formula weight: 122583.18

Authors

Xia, L.,Lin, H.,Panjikar, S.,Ruppert, M.,Castiglia, A.,Rajendran, C.,Wang, M.,Schuebel, H.,Warzecha, H.,Jaeger, V.,Stoeckigt, J. (deposition date: 2013-01-17, release date: 2014-02-05, Last modification date: 2023-12-20)

• Primary citation: Xia, L.,Lin, H.,Staniek, A.,Panjikar, S.,Ruppert, M.,Hilgers, P.,Williardt, J.,Rajendran, C.,Wang, M.,Warzecha, H.,Jager, V.,Stockigt, J.; Ligand Structures of Synthetic Deoxa-Pyranosylamines with Raucaffricine and Strictosidine Glucosidases Provide Structural Insights Into Their Binding and Inhibitory Behaviours.; J.Enzyme.Inhib.Med.Chem., 30:472-, 2015; PubMed: 25140865; DOI: 10.3109/14756366.2014.949252

Experimental method

X-RAY DIFFRACTION (3.01 Å)