3ZFO

Crystal structure of substrate-like, unprocessed N-terminal protease Npro mutant S169P

Summary for 3ZFO

Entry DOI	10.2210/pdb3zfo/pdb
Related	3ZFN 3ZFP 3ZFQ 3ZFR 3ZFT 3ZFU
Descriptor	N-TERMINAL PROTEASE NPRO, MONOTHIOGLYCEROL, CHLORIDE ION, ... (5 entities in total)
Functional Keywords	hydrolase, auto-processing cysteine protease, viral protease, in cis- cleavage, hydroxide-dependent catalysis, auto-proteolysis, immune modulation, host-pathogen interaction, convergent evolution
Biological source	PESTIVIRUS STRAIN D32/00_HOBI
Total number of polymer chains	1
Total formula weight	18556.71
Authors	Zogg, T.,Sponring, M.,Schindler, S.,Koll, M.,Schneider, R.,Brandstetter, H.,Auer, B. (deposition date: 2012-12-12, release date: 2013-05-15, Last modification date: 2023-12-20)
Primary citation	Zogg, T.,Sponring, M.,Schindler, S.,Koll, M.,Schneider, R.,Brandstetter, H.,Auer, B. Crystal Structures of the Viral Protease Npro Imply Distinct Roles for the Catalytic Water in Catalysis Structure, 21:929-, 2013 Cited by PubMed: 23643950 DOI: 10.1016/J.STR.2013.04.003 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.01 Å)

Structure validation