3ZCL
X-ray Structure of c-Met kinase in complex with inhibitor (S)-3-(1-(1H-pyrrolo(2,3-b)pyridin-3-yl)ethyl)-N-isopropyl-(1,2,4)triazolo(4,3- b)pyridazin-6-amine
Summary for 3ZCL
Entry DOI | 10.2210/pdb3zcl/pdb |
Descriptor | HEPATOCYTE GROWTH FACTOR RECEPTOR, (S)-3-(1-(1H-pyrrolo(2,3-b)pyridin-3-yl)ethyl)-N-isopropyl-(1,2,4)triazolo(4,3-b)pyridazin-6-amine (3 entities in total) |
Functional Keywords | transferase, inhibitor |
Biological source | HOMO SAPIENS (HUMAN) |
Total number of polymer chains | 1 |
Total formula weight | 35200.79 |
Authors | McTigue, M.,Grodsky, N.,Ryan, K. (deposition date: 2012-11-20, release date: 2013-11-27, Last modification date: 2023-12-20) |
Primary citation | Cui, J.J.,Shen, H.,Tran-Dube, M.,Nambu, M.,Mctigue, M.,Grodsky, N.,Ryan, K.,Yamazaki, S.,Aguirre, S.,Parker, M.,Li, Q.,Zou, H.,Christensen, J. Lessons from (S)-6-(1-(6-(1-Methyl-1H-Pyrazol-4-Yl)-[1,2, 4]Triazolo[4,3-B]Pyridazin-3-Yl)Ethyl)Quinoline (Pf-04254644), an Inhibitor of Receptor Tyrosine Kinase C-met with High Protein Kinase Selectivity But Broad Phosphodiesterase Family Inhibition Leading to Myocardial Degeneration in Rats. J.Med.Chem., 56:6651-, 2013 Cited by PubMed: 23944843DOI: 10.1021/JM400926X PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.4 Å) |
Structure validation
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