3ZCL
X-ray Structure of c-Met kinase in complex with inhibitor (S)-3-(1-(1H-pyrrolo(2,3-b)pyridin-3-yl)ethyl)-N-isopropyl-(1,2,4)triazolo(4,3- b)pyridazin-6-amine
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | HEPATOCYTE GROWTH FACTOR RECEPTOR | polymer | 306 | 34879.4 | 1 | UniProt (P08581) Pfam (PF07714) In PDB | HOMO SAPIENS (HUMAN) | HGF RECEPTOR, HGF/SF RECEPTOR, PROTO-ONCOGENE C-MET, SCATTER FACTOR RECEPTOR, SF RECEPTOR, TYROSINE-PROTEIN KINASE MET |
2 | A | (S)-3-(1-(1H-pyrrolo(2,3-b)pyridin-3-yl)ethyl)-N-isopropyl-(1,2,4)triazolo(4,3-b)pyridazin-6-amine | non-polymer | 321.4 | 1 | Chemie (5TF) | |||
3 | water | water | 18.0 | 336 | Chemie (HOH) |
Sequence modifications
A: 1051 - 1348 (UniProt: P08581)
PDB | External Database | Details |
---|---|---|
Met 1050 | - | expression tag |
His 1349 | - | expression tag |
His 1350 | - | expression tag |
His 1351 | - | expression tag |
His 1352 | - | expression tag |
His 1353 | - | expression tag |
His 1354 | - | expression tag |
His 1355 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 34879.4 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 321.4 | |
All* | Total formula weight | 35200.8 |