3WT5

A mixed population of antagonist and agonist binding conformers in a single crystal explains partial agonism against vitamin D receptor: Active vitamin D analogues with 22R-alkyl group

3WT5 の概要

• エントリーDOI: 10.2210/pdb3wt5/pdb
• 関連するPDBエントリー: 3WT6 3WT7
• 分子名称: Vitamin D3 receptor, Mediator of RNA polymerase II transcription subunit 1, (1R,3R,7E,17beta)-17-[(2R,3R)-3-butyl-6-hydroxy-6-methylheptan-2-yl]-2-methylidene-9,10-secoestra-5,7-diene-1,3-diol, ... (4 entities in total)
• 機能のキーワード: transcription, vitamin d3, vdre, rxr, co-factors, nuclear
• 由来する生物種: Rattus norvegicus (rats); 詳細
• 細胞内の位置: Nucleus: P13053 Q15648
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 32638.68

構造登録者

Anami, Y.,Itoh, T.,Yamamoto, K. (登録日: 2014-04-08, 公開日: 2014-06-11, 最終更新日: 2024-03-20)

• 主引用文献: Anami, Y.,Itoh, T.,Egawa, D.,Yoshimoto, N.,Yamamoto, K.; A Mixed Population of Antagonist and Agonist Binding Conformers in a Single Crystal Explains Partial Agonism against Vitamin D Receptor: Active Vitamin D Analogues with 22R-Alkyl Group.; J.Med.Chem., 57:4351-4367, 2014; PubMed: 24742174; DOI: 10.1021/jm500392t

実験手法

X-RAY DIFFRACTION (1.9 Å)