3WSB
The Tuberculosis Drug SQ109 Inhibits Trypanosoma cruzi Cell Proliferation and acts Synergistically with Posaconazole
Summary for 3WSB
Entry DOI | 10.2210/pdb3wsb/pdb |
Related | 3WSA |
Descriptor | Farnesyltransferase, putative, S-[(2E,6E)-3,7,11-TRIMETHYLDODECA-2,6,10-TRIENYL] TRIHYDROGEN THIODIPHOSPHATE, N-[(2Z)-3,7-dimethylocta-2,6-dien-1-yl]-N'-[(1R,3S,5R,7R)-tricyclo[3.3.1.1~3,7~]dec-2-yl]ethane-1,2-diamine, ... (4 entities in total) |
Functional Keywords | isoprenoids, drug discovery, trypanosoma cruzi squalene synthase, sq109, fspp, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Trypanosoma cruzi |
Total number of polymer chains | 4 |
Total formula weight | 170363.01 |
Authors | Shang, N.,Li, Q.,Huang, C.H.,Oldfield, E.,Guo, R.T. (deposition date: 2014-03-05, release date: 2015-04-01, Last modification date: 2023-11-08) |
Primary citation | Shang, N.,Li, Q.,Huang, C.H.,Oldfield, E.,Guo, R.T. The Tuberculosis Drug SQ109 Inhibits Trypanosoma cruzi Cell Proliferation and acts Synergistically with Posaconazole To be Published, |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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