3WIG
Human MEK1 kinase in complex with CH5126766 and MgAMP-PNP
Summary for 3WIG
Entry DOI | 10.2210/pdb3wig/pdb |
Related | 3ORN 3OS3 |
Descriptor | Dual specificity mitogen-activated protein kinase kinase 1, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, MAGNESIUM ION, ... (7 entities in total) |
Functional Keywords | kinase, kinase inhibitor, allosteric, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 1 |
Total formula weight | 35612.89 |
Authors | Lukacs, C.M.,Janson, C.,Schuck, V. (deposition date: 2013-09-12, release date: 2014-06-04, Last modification date: 2024-03-20) |
Primary citation | Lito, P.,Saborowski, A.,Yue, J.,Solomon, M.,Joseph, E.,Gadal, S.,Saborowski, M.,Kastenhuber, E.,Fellmann, C.,Ohara, K.,Morikami, K.,Miura, T.,Lukacs, C.,Ishii, N.,Lowe, S.,Rosen, N. Disruption of CRAF-Mediated MEK Activation Is Required for Effective MEK Inhibition in KRAS Mutant Tumors Cancer Cell, 25:697-710, 2014 Cited by PubMed: 24746704DOI: 10.1016/j.ccr.2014.03.011 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.7 Å) |
Structure validation
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