3WIG

Human MEK1 kinase in complex with CH5126766 and MgAMP-PNP

Summary for 3WIG

Entry DOI	10.2210/pdb3wig/pdb
Related	3ORN 3OS3
Descriptor	Dual specificity mitogen-activated protein kinase kinase 1, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, MAGNESIUM ION, ... (7 entities in total)
Functional Keywords	kinase, kinase inhibitor, allosteric, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (human) More
Total number of polymer chains	1
Total formula weight	35612.89
Authors	Lukacs, C.M.,Janson, C.,Schuck, V. (deposition date: 2013-09-12, release date: 2014-06-04, Last modification date: 2024-03-20)
Primary citation	Lito, P.,Saborowski, A.,Yue, J.,Solomon, M.,Joseph, E.,Gadal, S.,Saborowski, M.,Kastenhuber, E.,Fellmann, C.,Ohara, K.,Morikami, K.,Miura, T.,Lukacs, C.,Ishii, N.,Lowe, S.,Rosen, N. Disruption of CRAF-Mediated MEK Activation Is Required for Effective MEK Inhibition in KRAS Mutant Tumors Cancer Cell, 25:697-710, 2014 Cited by PubMed: 24746704 DOI: 10.1016/j.ccr.2014.03.011 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.7 Å)

Structure validation