3WIG
Human MEK1 kinase in complex with CH5126766 and MgAMP-PNP
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Dual specificity mitogen-activated protein kinase kinase 1 | polymer | 307 | 34239.4 | 1 | UniProt (Q02750) Pfam (PF00069) In PDB | Homo sapiens (human) | MAP kinase kinase 1, MAPKK 1, MKK1, ERK activator kinase 1, MAPK/ERK kinase 1, MEK 1 |
2 | A | PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | non-polymer | 506.2 | 1 | Chemie (ANP) | |||
3 | A | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
4 | A | N-(3-fluoro-4-{[4-methyl-2-oxo-7-(pyrimidin-2-yloxy)-2H-chromen-3-yl]methyl}pyridin-2-yl)-N'-methylsulfuric diamide | non-polymer | 471.5 | 1 | Chemie (CHU) | |||
5 | A | TETRAETHYLENE GLYCOL | non-polymer | 194.2 | 1 | Chemie (PG4) | |||
6 | A | CHLORIDE ION | non-polymer | 35.5 | 5 | Chemie (CL) | |||
7 | water | water | 18.0 | 16 | Chemie (HOH) |
Sequence modifications
A: 63 - 302 (UniProt: Q02750)
A: 303 - 393 (UniProt: Q02750)
PDB | External Database | Details |
---|---|---|
Met 62 | - | expression tag |
PDB | External Database | Details |
---|---|---|
His 394 | - | expression tag |
His 395 | - | expression tag |
His 396 | - | expression tag |
His 397 | - | expression tag |
His 398 | - | expression tag |
His 399 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 34239.4 | |
Non-Polymers* | Number of molecules | 9 |
Total formula weight | 1373.5 | |
All* | Total formula weight | 35612.9 |