3WHW
MTH1 in complex with Ruthenium-based inhibitor
Summary for 3WHW
Entry DOI | 10.2210/pdb3whw/pdb |
Related | 3ZR1 |
Descriptor | 7,8-dihydro-8-oxoguanine triphosphatase, SULFATE ION, [4-amino-2-methyl-6-(pyridin-2-yl-kappaN)quinazolin-7-yl-kappaC~7~](carbonyl){1-[(2,6-dimethoxyphenoxy)carbonyl]cyclopenta-2,4-dien-1-yl}ruthenium, ... (4 entities in total) |
Functional Keywords | mth1, organometallic inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Isoform p18: Cytoplasm. Isoform p26: Cytoplasm: P36639 |
Total number of polymer chains | 2 |
Total formula weight | 37834.55 |
Authors | Streib, M.,Kraeling, K.,Richter, K.,Steuber, H.,Meggers, E. (deposition date: 2013-09-03, release date: 2014-02-12, Last modification date: 2023-11-08) |
Primary citation | Streib, M.,Kraeling, K.,Richter, K.,Xie, X.,Steuber, H.,Meggers, E. An Organometallic Inhibitor for the Human Repair Enzyme 7,8-Dihydro-8-oxoguanosine Triphosphatase. Angew.Chem.Int.Ed.Engl., 53:305-309, 2014 Cited by PubMed: 24258965DOI: 10.1002/anie.201307849 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.701 Å) |
Structure validation
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