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3WHW

MTH1 in complex with Ruthenium-based inhibitor

Functional Information from GO Data
ChainGOidnamespacecontents
A0001669cellular_componentacrosomal vesicle
A0003723molecular_functionRNA binding
A0005515molecular_functionprotein binding
A0005615cellular_componentextracellular space
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005759cellular_componentmitochondrial matrix
A0005829cellular_componentcytosol
A0006152biological_processpurine nucleoside catabolic process
A0006281biological_processDNA repair
A0006979biological_processresponse to oxidative stress
A0008413molecular_function8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity
A0008584biological_processmale gonad development
A0008828molecular_functiondATP diphosphatase activity
A0016787molecular_functionhydrolase activity
A0016818molecular_functionhydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
A0030515molecular_functionsnoRNA binding
A0031965cellular_componentnuclear membrane
A0035539molecular_function8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity
A0042262biological_processDNA protection
A0046686biological_processresponse to cadmium ion
A0046872molecular_functionmetal ion binding
A0047693molecular_functionATP diphosphatase activity
A0106377molecular_function2-hydroxy-ATP hydrolase activity
A0106378molecular_function2-hydroxy-dATP hydrolase activity
A0106431molecular_functionN6-methyl-(d)ATP hydrolase activity
A0106433molecular_functionO6-methyl-dGTP hydrolase activity
A0140933molecular_function5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity
B0001669cellular_componentacrosomal vesicle
B0003723molecular_functionRNA binding
B0005515molecular_functionprotein binding
B0005615cellular_componentextracellular space
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005739cellular_componentmitochondrion
B0005759cellular_componentmitochondrial matrix
B0005829cellular_componentcytosol
B0006152biological_processpurine nucleoside catabolic process
B0006281biological_processDNA repair
B0006979biological_processresponse to oxidative stress
B0008413molecular_function8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity
B0008584biological_processmale gonad development
B0008828molecular_functiondATP diphosphatase activity
B0016787molecular_functionhydrolase activity
B0016818molecular_functionhydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
B0030515molecular_functionsnoRNA binding
B0031965cellular_componentnuclear membrane
B0035539molecular_function8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity
B0042262biological_processDNA protection
B0046686biological_processresponse to cadmium ion
B0046872molecular_functionmetal ion binding
B0047693molecular_functionATP diphosphatase activity
B0106377molecular_function2-hydroxy-ATP hydrolase activity
B0106378molecular_function2-hydroxy-dATP hydrolase activity
B0106431molecular_functionN6-methyl-(d)ATP hydrolase activity
B0106433molecular_functionO6-methyl-dGTP hydrolase activity
B0140933molecular_function5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity
Functional Information from PDB Data
site_idAC1
Number of Residues5
DetailsBINDING SITE FOR RESIDUE SO4 A 201
ChainResidue
AALA63
AHIS65
ATHR88
AASP89
ASER90

site_idAC2
Number of Residues5
DetailsBINDING SITE FOR RESIDUE SO4 A 202
ChainResidue
BVAL96
AVAL153
AASP154
ATHR155
BPRO95

site_idAC3
Number of Residues3
DetailsBINDING SITE FOR RESIDUE SO4 A 203
ChainResidue
AHIS65
ALYS66
ALYS132

site_idAC4
Number of Residues15
DetailsBINDING SITE FOR RESIDUE RUX A 204
ChainResidue
ATYR7
ATHR8
ALEU9
ALYS23
APHE27
AGLY28
AASN33
AGLY34
AGLY37
ALYS38
AMET81
AMET116
AASP119
AASP120
ATRP123

site_idAC5
Number of Residues3
DetailsBINDING SITE FOR RESIDUE SO4 B 201
ChainResidue
BHIS134
BARG151
BHOH301

site_idAC6
Number of Residues4
DetailsBINDING SITE FOR RESIDUE SO4 B 202
ChainResidue
BARG151
BVAL153
BASP154
BTHR155

site_idAC7
Number of Residues3
DetailsBINDING SITE FOR RESIDUE SO4 B 203
ChainResidue
BLEU64
BHIS65
BLYS66

site_idAC8
Number of Residues5
DetailsBINDING SITE FOR RESIDUE SO4 B 204
ChainResidue
BALA63
BHIS65
BTHR88
BASP89
BSER90

site_idAC9
Number of Residues15
DetailsBINDING SITE FOR RESIDUE RUX B 205
ChainResidue
BTYR7
BTHR8
BLEU9
BLYS23
BPHE27
BGLY28
BASN33
BGLY34
BGLY36
BGLY37
BLYS38
BPHE72
BMET81
BASP119
BASP120

Functional Information from PROSITE/UniProt
site_idPS00893
Number of Residues22
DetailsNUDIX_BOX Nudix box signature. GkvqegEtiedGArRELqEEsG
ChainResidueDetails
AGLY37-GLY58

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues8
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:Q7ZWC3
ChainResidueDetails
BLEU11
BGLN14
BPRO15
BLEU59
ALEU11
AGLN14
APRO15
ALEU59

site_idSWS_FT_FI2
Number of Residues2
DetailsBINDING: BINDING => ECO:0000269|PubMed:30304478, ECO:0007744|PDB:5OTM
ChainResidueDetails
AGLY76
BGLY76

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PDB entries from 2024-06-12

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