3WDZ

Crystal Structure of Keap1 in Complex with phosphorylated p62

Summary for 3WDZ

• Entry DOI: 10.2210/pdb3wdz/pdb
• Related: 1X2J 3ADE
• Descriptor: Kelch-like ECH-associated protein 1, Peptide from Sequestosome-1 (3 entities in total)
• Functional Keywords: kelch repeat, transcription, p62, nucleus
• Biological source: Mus musculus (mouse); More
• Cellular location: Cytoplasm: Q9Z2X8 Q64337
• Total number of polymer chains: 2
• Total formula weight: 35881.73

Authors

Fukutomi, T.,Takagi, K.,Mizushima, T.,Tanaka, K.,Komatsu, M.,Yamamoto, M. (deposition date: 2013-06-26, release date: 2013-09-04, Last modification date: 2023-11-08)

• Primary citation: Ichimura, Y.,Waguri, S.,Sou, Y.S.,Kageyama, S.,Hasegawa, J.,Ishimura, R.,Saito, T.,Yang, Y.,Kouno, T.,Fukutomi, T.,Hoshii, T.,Hirao, A.,Takagi, K.,Mizushima, T.,Motohashi, H.,Lee, M.S.,Yoshimori, T.,Tanaka, K.,Yamamoto, M.,Komatsu, M.; Phosphorylation of p62 activates the Keap1-Nrf2 pathway during selective autophagy.; Mol.Cell, 51:618-631, 2013; PubMed: 24011591; DOI: 10.1016/j.molcel.2013.08.003

Experimental method

X-RAY DIFFRACTION (2.6 Å)